CDC Drafts Guidelines to Reduce HIV, HBV, HCV Transmission
The Centers for Disease Control and Prevention (CDC) recently announced new draft guidelines for reducing transmission of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) through solid organ transplantation. The guidelines are meant for organ procurement organizations (OPOs); transplant centers; laboratory personnel responsible for testing and storing donor and recipient specimens; and anyone responsible for developing, implementing, and evaluating infection prevention and control programs for OPOs and transplant centers.
The 2011 Draft Guidelines, which were three years in the making, are an update of the “Guidelines for Preventing Transmission of Human Immunodeficiency Virus (HIV) through Transplantation of Human Tissue and Organs,” released in 1994. Previous recommendations for HIV have been revised, and recommendations to reduce disease transmission of HBV and HCV have been added. Like the previous guidelines, the 2011 draft addresses adult and pediatric donors who are living or deceased, as well as transplant candidates and recipients.
The new guidelines additionally include:
- A seven-step donor risk assessment process
- A nine-step donor screening process
- Required recipient informed consent and testing
- Recommendations for donor and recipient specimen collection and storage
- Guidelines for HBV and HCV-infected donors and transplantation
- A 12-step process for tracking and reporting of HIV, HBV, and HCV
The draft guidelines also offer 14 points for further research, including “Estimate the incidence and prevalence of HIV, HBV and HCV among deceased potential organ donors in the United States” and “Assess interventions (e.g., pathogen reduction methods) to reduce or eliminate the viral burden of HIV, HBV, and HCV in donors or donor organs before or after recovery, but prior to transplantation.”
CDC is accepting public comments on the draft guidelines, and encourages participation from anyone involved in transplantation. The deadline for comments is Nov. 21, 2011.