Can modifier -22 be used with coding services performed by a physician in an ASC setting? My impression is that it is not allowed since it is not approved in the outpatient or the ASC settings, per AMA CPT guidelines. Beckers-ASC's list of modifiers for physician and facility coding in the ASC setting also does not have modifier -22 included. However, I have been informed by a seasoned medical coder that it can be used for an ASC setting. Someone please clarify.