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Thread: 88368 - one unit or two

  1. #1

    Default 88368 - one unit or two

    AAPC: Back to School
    Fluorescence in situ hybridization (FISH) analysis was performed on a
    formalin-fixed Block 1A (Breast Cancer) using the DNA probe for the HER-2/NEU
    gene (Vysis, Inc., lot # 417686). An adequate number of invasive tumor cells
    were present and evaluated by two independent observers. The ratio of
    HER-2/NEU signals (ERBB2) to chromosome 17 centromere signals (D17Z1) was
    determined to be 1.26. A ratio of greater than 2.2 is considered to be
    amplified; therefore, this specimen is not amplified. Although amplification
    was not seen, many of the cells exhibited 3 or more signals for both the
    HER-2/NEU gene and for the chromosome 17 centromere. This may be indicative
    of either polyploidy or aneuploidy for chromosome 17. The average number of
    HER-2/NEU signals per cell was 5.83. The average number of signals for the
    chromosome 17 centromere was 4.63.

  2. #2
    Join Date
    Apr 2007
    New Orleans, LA


    Its billed each probe. Without making my head spin reading through all that again, aren't you only performing the FISH on HER-2/Neu? That would only be x1. Are you thinking x2 because two different people evaluated it? I wouldn't.

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