We use 52 modifier on the drug itself with "adverse reaction to drug" or similar comment under Additional info to get reimbursed at a reduced rate for the drug that was mixed but not used and that cannot be returned. We bill for the documented time of the infusion. For example, if a patient had a reaction after 12 minutes, we would bill 96409 (even if it was supposed to be 3 hour infusion).
With that said, it might be helpful to place a call to the payer and see what are their policies regarding scenarios like this. Our local Medicaid doesn't recognize 52 mod, so we submit claims with "adverse reaction to drug" comment/ no modifier/ and CPT code that reflects documented time of the infusion. Best regards.
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