CPT^® 81291, Under Genetic Analysis Procedures

The Current Procedural Terminology (CPT^®) code 81291 as maintained by American Medical Association, is a medical procedural code under the range - Genetic Analysis Procedures.

Additional/Related Information

Tabs

Summary

The lab analyst performs the technical lab test to detect the presence of common changes in the gene for 5,10–methylenetetrahydrofolate reductase, also known as MTHFR.

For clinical responsibility, terminology, tips and additional info
start codify free trial.

View any code changes for 2026 as well as historical information on code creation and revision.

Crosswalks

Tabs

MODIFIERS
ICD-10-CM

Combat the #1 denial reason - mismatched CPT-ICD-9 codes - with top Medicare carrier and private payer accepted diagnoses for the chosen CPT® code.

View the CPT® code's corresponding procedural code and DRG. In a click, check the DRG's IPPS allowable, length of stay, and more. To plug inpatient facility revenue drains, subscribe to DRG Coder today.

Crosswalk to an anesthesia code and its base units, and calculate payments in a snap! Subscribe to Anesthesia Coder today.

View matching HCPCS Level II codes and their definitions.

Forum

Have a question about CPT Code 81291 ? Start a discussion here

NC Medicaid DNA reimbursements?

Good Morning. This is my first time posting so I hope I am doing this correctly. I work at a lab and we have received 2 very large payments from NC Medicaid where Medicare has denied the DNA claim a... [ Read More ]

Molecular Pathology Billing/Coding

Molecular Pathology procedures. We are a Tier 3 Lab. This is not my forte but I have been assigned this task of fixing this coding and billing issue. Any help and guidance would be appreciated. ... [ Read More ]

View All