Wiki 59 modifier

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I work for a genetic testing laboratory, we currently bill CPT 81229 (CMA) and 81243 (Fragile-X) together and we have always billed these with a 59 modifier on the 81243 with great success. Recently, we have had a couple of Regence payers deny the 81243 -59 as inappropriate coding combination, so we removed the modifier and now it is being denied as inclusive.

Does anyone else have this issue or even something similar? If so your advice would be greatly appreciated.

We have considered the X modifiers but none of them seem appropriate for our situation.
 
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