Wiki Question on why a 25 modifier wasn't needed for both scenarios

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I am new to coding and getting experience working in billing for a trauma surgeons practice. I use the Mckesson Clear Claim Connection through the BCBS website.

When I input 99221-57 and 25600-RT both codes are allowed.

When I input 99221-57 and 28400-50 the 99221 is disallowed unless I add a 25.

I am confused as to why the 25 was only needed in the second scenario.

Any help or clarification would be greatly appreciated!
 
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