The mouth and throat are numbed using an anesthetic spray. A hollow mouthpiece is placed in the mouth. The flexible fiberoptic endoscope is inserted and advanced as it is swallowed by the patient. Once the endoscope has been advanced beyond the cricopharyngeal region, it is guided using direct visualization. The esophagus is inspected and any abnormalities are noted. The endoscope is then advanced into the stomach and the stomach is insufflated with air. The cardia, fundus, greater and lesser curvature, and antrum of the stomach are inspected and any abnormalities noted. The tip of the endoscope is passed through the pylorus into the duodenum or into the jejunum in the case of a surgically altered stomach where the jejunum is examined distal to the anastomosis. The mucosal surfaces are inspected. The scope is then withdrawn and the entire circumference of the duodenum or jejunum (where the stomach has been surgically altered), stomach, and esophagus are again examined.
Following endoscopic examination, an echoendoscope is introduced and any abnormalities or lesions are again carefully evaluated. Ultrasound images are obtained to determine whether the abnormality or lesion is intrinsic (within) or extrinsic (outside) the upper gastrointestinal tract. If the lesion is intrinsic, it is evaluated to determine whether it is limited to the mucosa or involves the muscular wall. If it is extrinsic, it is evaluated to determine whether it is in the mediastinal space or has invaded the mediastinal wall, what thoracic organs are involved, and whether there is any lymph node involvement. If it is in the stomach or small intestines, the lesion is evaluated in the same manner to determine whether invasion is limited to the peritoneal cavity or whether other sites and/or structures are involved. Hard copies of ultrasound images are made and the abnormalities are again evaluated.