80307 describes a method of presumptive drug screening that will not meet the requirements of a CLIA Waived procedure/device- so no "QW" modifier. Double check your CLIA# on the claim to make sure there isn't an error as well...
80305, 80306, 80307 are codes that represent presumptive screening..
G0480-G0483 and the 80320-80375 (AMA Codes) represent definitive testing --
No modifier is needed when billing presumptive and definitive testing.. I would just ensure if you are a provider's office that the definitive drug testing codes are part of your contract, this can also be true of 80307 as some plans do not consider this test appropriate in the office setting because of the amount of fraud and abuse there has been.
Have you seen this publication by Aetna Better Health?
Examples of inappropriate urine drug testing and/or abuse of urine drug testing:
The routine use of large, arbitrary test panels
Ordering confirmatory tests instead of presumptive tests
Ordering confirmatory tests on presumptive screens that are positive for an expected substance (e.g.
suboxone present in a patient receiving suboxone therapy)
Unnecessarily frequent drug testing without consideration for the drug’s window of detection
Ordering daily urine drug screens
Ordering weekly urine drug screens on patients that have been established in treatment and have routinely
been having expected urine drug screens results
The confirmation and quantification of all presumptive positive and negative test results
Ordering a confirmatory test for more substances than what tested positive in the presumptive test.
Ordering multiple drug screens on the same DOS (e.g. ordering 80305 and 80307 on the same day)
Unbundling drug screens and billing each substance individually
Aetna's policy is pretty restrictive, especially in the substance abuse space. The modifier probably triggered the denial, but I would be cautious of the frequency of testing and the use of definitive testing without the proper documentation to support it.